WNK1

Across TCGA cell cohorts, WNK1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,084 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible WNK1-associated GO terms across cancer lineages are Positive regulation of mitotic cytokinesis, Protein-DNA complex organization, and Negative regulation of gene expression, epigenetic. Each is linked with WNK1 in more than 17 cancer types. Because this analysis shows association rather than direction, both WNK1-to-partner and partner-to-WNK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of mitotic cytokinesis grouped by WNK1-low versus WNK1-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (WNK1→partner) and Y-score (partner→WNK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Positive regulation of mitotic cytokinesis →	+0.191	+1.405	<.001	<.001	3	17
STOMACH	Protein-DNA complex organization →	+0.059	+1.094	.007	.004	1	18
BONE	Negative regulation of gene expression, epigenetic →	+0.079	+0.659	.003	.009	2	17
UPPER_AERODIGESTIVE_TRACT	Transcription initiation-coupled chromatin remodeling →	+0.129	+1.283	<.001	<.001	3	16
STOMACH	Heterochromatin organization →	+0.069	+1.115	.001	.001	3	16
OVARY	Regulation of nucleotide-excision repair →	+0.111	+0.963	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,084 associations by consensus.

Positive regulation of mitotic cytokinesis by WNK1 expression — STOMACH

Explore this box plot interactively →