WNK1

Across TCGA cell cohorts, WNK1 mutation is significantly associated with the RNA expression of many other genes, with 2,641 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible WNK1-associated genes across cancer lineages are FGF23, SLC25A51, and RAP1GDS1. Each is linked with WNK1 in more than 2 cancer types. Because this analysis shows association rather than direction, both WNK1-to-partner and partner-to-WNK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FGF23 grouped by WNK1-low versus WNK1-high in STOMACH.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WNK1→partner) and Y-score (partner→WNK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	FGF23 →	+0.058	+3.632	.003	.009	3	3
LARGE_INTESTINE	SLC25A51 →	+0.615	+1.808	<.001	.001	3	3
LARGE_INTESTINE	RAP1GDS1 →	+0.472	+1.808	.001	.001	3	3
CNS	OR1L3 →	+0.022	+3.285	<.001	.006	3	3
LARGE_INTESTINE	ZNF286B →	+0.882	+2.299	<.001	<.001	3	3
LUNG_NSCLC_LUAD	OR11H6 →	+0.034	+3.347	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,641 associations by consensus.

FGF23 by WNK1 expression — STOMACH

Explore this box plot interactively →