WIZ

Across TCGA patient cohorts, WIZ mutation is significantly associated with the RNA expression of many other genes, with 3,968 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WIZ-associated genes across cancer lineages are LMNB2, CKS2, and METTL5. Each is linked with WIZ in more than 3 cancer types. Because this analysis shows association rather than direction, both WIZ-to-partner and partner-to-WIZ results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LMNB2 grouped by WIZ-low versus WIZ-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WIZ→partner) and Y-score (partner→WIZ) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	LMNB2 →	+0.612	+1.917	<.001	<.001	3	4
UCEC	CKS2 →	+0.599	+1.722	<.001	<.001	3	3
CESC	METTL5 →	+0.503	+3.209	<.001	.008	3	3
SKCM	ZNF367 →	+0.765	+3.350	.001	.005	3	3
COAD	SNORA1B →	+0.633	+3.372	<.001	.001	3	3
UCEC	SPTY2D1 →	+0.414	+2.343	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,968 associations by consensus.

LMNB2 by WIZ expression — UCEC

Explore this box plot interactively →