WIZ

Across TCGA cell cohorts, WIZ RNA expression is significantly associated with the go_rna of many other GO terms, with 4,508 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible WIZ-associated GO terms across cancer lineages are Regulation of cell fate commitment, Positive regulation of cell fate commitment, and Positive regulation of T-helper 17 cell lineage commitment. Each is linked with WIZ in more than 17 cancer types. Because this analysis shows association rather than direction, both WIZ-to-partner and partner-to-WIZ results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of cell fate commitment grouped by WIZ-low versus WIZ-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (WIZ→partner) and Y-score (partner→WIZ) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Regulation of cell fate commitment →	+0.160	+0.737	<.001	<.001	3	18
UPPER_AERODIGESTIVE_TRACT	Positive regulation of cell fate commitment →	+0.196	+0.729	.005	.006	3	16
STOMACH	Positive regulation of T-helper 17 cell lineage commitment →	+0.231	+0.989	.002	.002	3	16
BONE	Regulation of chromatin organization →	+0.112	+0.870	<.001	.001	3	16
BLOOD_Leukemia	Positive regulation of double-strand break repair via homologous recombination →	+0.076	+0.784	<.001	<.001	3	16
BONE	CAMP/PKA signal transduction →	+0.234	+0.993	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,508 associations by consensus.

Regulation of cell fate commitment by WIZ expression — SOFT_TISSUE

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