WIZ

Across TCGA cell cohorts, WIZ mutation is significantly associated with the RNA expression of many other genes, with 1,220 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible WIZ-associated genes across cancer lineages are FGF23, GK2, and LMX1A. Each is linked with WIZ in more than 2 cancer types. Because this analysis shows association rather than direction, both WIZ-to-partner and partner-to-WIZ results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FGF23 grouped by WIZ-low versus WIZ-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WIZ→partner) and Y-score (partner→WIZ) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	FGF23 →	+0.153	+4.371	<.001	.005	3	3
LUNG_SCLC	GK2 →	+0.426	+2.428	.006	.007	3	3
UPPER_AERODIGESTIVE_TRACT	LMX1A →	+0.037	+4.870	<.001	.001	3	3
UPPER_AERODIGESTIVE_TRACT	PRAMEF15 →	+0.157	+4.357	<.001	.006	3	3
URINARY_TRACT	UNCX →	+0.010	+4.087	<.001	.009	3	2
STOMACH	CALN1 →	+0.627	+3.321	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,220 associations by consensus.

FGF23 by WIZ expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →