WIPI1

Across TCGA pan-cancer cohorts, WIPI1 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated WIPI1 data layer compared with 22 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher WIPI1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated WIPI1 expression acts as an unfavorable survival marker.

LUSC, LGG, and COAD are the cancer types where WIPI1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	OS	Median	II,III,IV	0.140	0.743	.001	24	view →
LGG	DFS	Median	All	0.172	0.845	<.001	9	view →
COAD	DFS	Median	All	0.215	0.696	.013	9	view →
ESCA	OS	Median	II,III,IV	0.216	0.702	.014	6	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

WIPI1–LUSC (OS)

Open the LUSC breakdown →