WIPI1

Across TCGA pan-cancer cohorts, WIPI1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated WIPI1 data layer compared with 22 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher WIPI1 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated WIPI1 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and PDAC show a favorable association.

CCRCC, GBM, and PDAC are the cancer types where WIPI1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Median	IV	1.000	0.451	.016	20	view →
GBM	OS	Median	All	0.407	0.652	.011	13	view →
PDAC	OS	Median	III,IV	1.000	0.537	.008	10	view →
LUAD	DFS	Tertile	II,III,IV	0.864	0.252	.035	6	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

WIPI1–CCRCC (OS)

Open the CCRCC breakdown →