WIPF1

Across TCGA cell cohorts, WIPF1 mutation is significantly associated with the RNA expression of many other genes, with 127 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible WIPF1-associated genes across cancer lineages are GCAT, HMGXB4, and EIF3D. Each is linked with WIPF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both WIPF1-to-partner and partner-to-WIPF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GCAT grouped by WIPF1-low versus WIPF1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WIPF1→partner) and Y-score (partner→WIPF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GCAT →	+1.129	+3.169	.004	.009	3	1
LARGE_INTESTINE	HMGXB4 →	+0.533	+3.502	.005	.001	3	1
LARGE_INTESTINE	EIF3D →	+0.394	+3.137	.008	.007	3	1
LARGE_INTESTINE	GNPNAT1 →	+0.523	+3.588	.006	<.001	3	1
LARGE_INTESTINE	R3HCC1 →	+0.652	+3.237	.009	.003	3	1
LARGE_INTESTINE	FAM149A →	+1.289	+3.502	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 127 associations by consensus.

GCAT by WIPF1 expression — LARGE_INTESTINE

Explore this box plot interactively →