WHSC1L2P

Across TCGA pan-cancer cohorts, WHSC1L2P RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of WHSC1L2P’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where WHSC1L2P RNA is repressed in tumor relative to normal tissue. In most cancer types WHSC1L2P is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

KICH, THCA, and KIRC are the cancer types where WHSC1L2P tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in WHSC1L2P RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	All	All	−0.245	<.001	7	view →
THCA	Male	All	−0.119	<.001	7	view →
KIRC	All	II,III,IV	−0.086	.006	5	view →
LUSC	All	All	+0.104	<.001	4	view →
LUAD	All	All	+0.086	.002	3	view →
HNSC	All	All	+0.041	.013	3	view →
LIHC	All	II,III,IV	+0.035	.008	3	view →
COAD	All	All	+0.047	.028	2	view →
PRAD	All	All	−0.042	.041	2	view →
STAD	All	II,III,IV	+0.078	.025	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

WHSC1L2P–KICH

Open the KICH breakdown →