WFS1

Across TCGA patient cohorts, WFS1 RNA expression is significantly associated with the protein abundance of many other proteins, with 13,991 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible WFS1-associated proteins across cancer lineages are WFS1_S235, WFS1_S32, and SPTAN1. Each is linked with WFS1 in more than 6 cancer types. Because this analysis shows association rather than direction, both WFS1-to-partner and partner-to-WFS1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, WFS1 versus WFS1_S235 in BRCA, with a Pearson correlation of 0.42.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (WFS1→partner) and Y-score (partner→WFS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	WFS1_S235 →	+1.705	+1.198	<.001	<.001	3	7
LUAD	WFS1_S32 →	+0.683	+0.382	.001	.001	3	5
GBM	SPTAN1 →	+0.345	+0.621	.001	.002	3	4
OV	EFHD1 →	+0.661	+0.960	.001	<.001	2	5
LUAD	UTRN →	+0.187	+0.369	<.001	<.001	3	4
BRCA	WDR12 →	-0.334	-0.948	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,991 associations by consensus.

WFS1 vs WFS1_S235 — BRCA

Explore this scatter interactively →