WFIKKN2

Across TCGA cell cohorts, WFIKKN2 mutation is significantly associated with the RNA expression of many other genes, with 40 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible WFIKKN2-associated genes across cancer lineages are AHSA1, PCCB, and OR56A5. Each is linked with WFIKKN2 in more than 1 cancer types. Because this analysis shows association rather than direction, both WFIKKN2-to-partner and partner-to-WFIKKN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AHSA1 grouped by WFIKKN2-low versus WFIKKN2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WFIKKN2→partner) and Y-score (partner→WFIKKN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	AHSA1 →	+0.486	+3.064	.002	.009	3	1
LARGE_INTESTINE	PCCB →	+0.688	+3.125	<.001	.008	3	1
LUNG_NSCLC_LUAD	OR56A5 →	+0.111	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	TMEM207 →	+0.095	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	CXorf51A →	+0.055	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	IQCF3 →	+0.045	+5.228	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

AHSA1 by WFIKKN2 expression — LARGE_INTESTINE

Explore this box plot interactively →