WFIKKN2

Across TCGA pan-cancer cohorts, WFIKKN2 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated WFIKKN2 data layer compared with 5 for mutation status.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher WFIKKN2 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated WFIKKN2 expression acts as an unfavorable survival marker, although some lineages such as KIRP and UCS show a favorable association.

KIRC, KIRP, and UCS are the cancer types where WFIKKN2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Tertile	II,III,IV	0.592	0.851	<.001	81	view →
KIRP	DFS	Median	All	0.963	0.859	<.001	74	view →
UCS	OS	Median	II,III,IV	0.690	0.316	.005	60	view →
STAD	OS	Tertile	All	0.483	0.625	.004	58	view →
LGG	OS	Median	All	0.745	0.877	<.001	49	view →
ACC	OS	Tertile	II,III,IV	0.236	1.000	<.001	38	view →
CHOL	OS	Median	II,III,IV	0.252	0.734	.004	24	view →
LUAD	OS	Tertile	All	0.865	0.769	.002	22	view →
THCA	DFS	Quartile	All	0.923	0.616	.013	21	view →
COAD	DFS	Median	All	0.732	0.821	.008	16	view →
READ	DFS	Quartile	III,IV	0.225	1.000	.003	16	view →
DLBC	DFS	Quartile	All	0.651	0.859	.034	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

WFIKKN2–KIRC (DFS)

Open the KIRC breakdown →