WFIKKN2

Across TCGA cell cohorts, WFIKKN2 mutation is significantly associated with the mutation status of many other genes, with 4,868 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible WFIKKN2-associated genes across cancer lineages are LAMB1, BNC2, and REXO1. Each is linked with WFIKKN2 in more than 3 cancer types. Because this analysis shows association rather than direction, both WFIKKN2-to-partner and partner-to-WFIKKN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LAMB1 grouped by WFIKKN2-low versus WFIKKN2-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WFIKKN2→partner) and Y-score (partner→WFIKKN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	LAMB1 →	+4.857	+4.297	.009	.009	1	4
LUNG_NSCLC_LUAD	BNC2 →	+4.187	+5.000	.008	.008	1	4
LARGE_INTESTINE	REXO1 →	+2.047	+2.510	.004	.004	1	4
LARGE_INTESTINE	ADAMTSL1 →	+1.714	+3.993	<.001	<.001	1	4
LARGE_INTESTINE	USP34 →	+1.462	+2.823	.003	.003	1	4
LARGE_INTESTINE	WDR33 →	+1.980	+2.807	.001	.001	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,868 associations by consensus.

LAMB1 by WFIKKN2 expression — BREAST

Explore this box plot interactively →