WFIKKN1

Across TCGA pan-cancer cohorts, WFIKKN1 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated WFIKKN1 data layer compared with 20 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher WFIKKN1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated WFIKKN1 expression acts as an unfavorable survival marker.

LUSC, SKCM, and ESCA are the cancer types where WFIKKN1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	OS	Median	All	0.031	0.776	<.001	24	view →
SKCM	OS	Median	All	0.245	0.783	.007	21	view →
ESCA	OS	Median	II,III,IV	0.105	0.867	.016	6	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

WFIKKN1–LUSC (OS)

Open the LUSC breakdown →