WFIKKN1

Across TCGA pan-cancer cohorts, WFIKKN1 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of WFIKKN1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where WFIKKN1 RNA is repressed in tumor relative to normal tissue. In most cancer types WFIKKN1 is over-expressed in tumor, although a few such as KIRP and THCA show the opposite, repressed pattern.

KIRP, THCA, and LUAD are the cancer types where WFIKKN1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in WFIKKN1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	Male	All	−0.565	<.001	11	view →
THCA	Male	All	−0.555	<.001	11	view →
LUAD	Male	All	−0.511	<.001	7	view →
KIRC	All	All	+0.282	.009	6	view →
BRCA	All	II,III,IV	+0.223	<.001	6	view →
LIHC	All	All	+0.186	.001	5	view →
STAD	All	All	+0.398	.002	3	view →
CHOL	Female	All	+0.546	.001	2	view →
PRAD	All	All	+0.192	.025	2	view →
COAD	All	IV	+0.464	.031	1	view →
HNSC	Male	IV	+0.231	.038	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

WFIKKN1–KIRP

Open the KIRP breakdown →