WFIKKN1

Across TCGA patient cohorts, WFIKKN1 mutation is significantly associated with the RNA expression of many other genes, with 503 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WFIKKN1-associated genes across cancer lineages are RNA5SP31, MIR4727, and RN7SL98P. Each is linked with WFIKKN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both WFIKKN1-to-partner and partner-to-WFIKKN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP31 grouped by WFIKKN1-low versus WFIKKN1-high in ESCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WFIKKN1→partner) and Y-score (partner→WFIKKN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	RNA5SP31 →	+0.332	+5.954	<.001	.002	3	2
UCEC	MIR4727 →	+0.289	+2.644	<.001	.005	3	2
UCEC	RN7SL98P →	+0.091	+2.359	.007	.005	3	2
HNSC	CICP6 →	+0.015	+5.124	<.001	.008	3	2
ESCA	MIR510 →	+0.546	+5.068	<.001	.008	3	1
ESCA	MIR154 →	+0.376	+6.709	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 503 associations by consensus.

RNA5SP31 by WFIKKN1 expression — ESCA

Explore this box plot interactively →