WFIKKN1

Across TCGA patient cohorts, WFIKKN1 mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WFIKKN1-associated genes across cancer lineages are FOXO3a_pS318_S321, HER3_pY1289, and PDK1_pS241. Each is linked with WFIKKN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both WFIKKN1-to-partner and partner-to-WFIKKN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FOXO3a_pS318_S321 grouped by WFIKKN1-low versus WFIKKN1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WFIKKN1→partner) and Y-score (partner→WFIKKN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FOXO3a_pS318_S321 →	-0.133	-3.169	.014	.018	3	1
UCEC	HER3_pY1289 →	+0.078	+2.189	.037	.034	3	1
UCEC	PDK1_pS241 →	+0.152	+1.598	.042	.044	3	1
UCEC	Rad50 →	-0.317	-2.115	.002	.019	3	1
UCEC	Annexin-1 →	+0.464	+3.169	.044	.018	3	1
UCEC	ARID1A →	-0.196	-2.577	.021	.011	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

FOXO3a_pS318_S321 by WFIKKN1 expression — UCEC

Explore this box plot interactively →