WFIKKN1

Across TCGA cell cohorts, WFIKKN1 mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible WFIKKN1-associated genes across cancer lineages are OR2T6, LRIT2, and SSTR4. Each is linked with WFIKKN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both WFIKKN1-to-partner and partner-to-WFIKKN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2T6 grouped by WFIKKN1-low versus WFIKKN1-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WFIKKN1→partner) and Y-score (partner→WFIKKN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	OR2T6 →	+0.023	+4.930	<.001	.008	3	1
BONE	LRIT2 →	+0.006	+5.169	<.001	.004	3	1
BLOOD_Leukemia	SSTR4 →	+0.061	+5.201	<.001	.006	3	1
BLOOD_Leukemia	KRT85 →	+0.059	+5.539	<.001	.003	3	1
BLOOD_Leukemia	OR7G2 →	+0.032	+5.201	<.001	.006	3	1
BLOOD_Leukemia	OR2AP1 →	+0.012	+5.539	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

OR2T6 by WFIKKN1 expression — SOFT_TISSUE

Explore this box plot interactively →