WFDC6

Across TCGA patient cohorts, WFDC6 mutation is significantly associated with the RNA expression of many other genes, with 78 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible WFDC6-associated genes across cancer lineages are RNU1-54P, OR4C7P, and C16orf78. Each is linked with WFDC6 in more than 1 cancer types. Because this analysis shows association rather than direction, both WFDC6-to-partner and partner-to-WFDC6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU1-54P grouped by WFDC6-low versus WFDC6-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WFDC6→partner) and Y-score (partner→WFDC6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RNU1-54P →	+0.099	+4.219	<.001	.006	3	2
SKCM	OR4C7P →	+0.019	+5.228	<.001	.001	3	2
SKCM	C16orf78 →	+0.065	+2.577	<.001	.007	3	1
SKCM	OR10A2 →	+0.035	+2.796	.006	.004	3	1
SKCM	OR2G3 →	+0.039	+3.748	<.001	.002	3	1
SKCM	OR56B3P →	+0.104	+2.617	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 78 associations by consensus.

RNU1-54P by WFDC6 expression — SKCM

Explore this box plot interactively →