WFDC6

Across TCGA pan-cancer cohorts, WFDC6 RNA is linked to patient survival in 17 of 34 cancer types, making it the most broadly survival-associated WFDC6 data layer compared with 1 for mutation status.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher WFDC6 RNA is associated with better overall survival. In most high-consensus cancer types, elevated WFDC6 expression acts as an unfavorable survival marker, although some lineages such as BLCA and UCEC show a favorable association.

BLCA, KIRC, and UCEC are the cancer types where WFDC6 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	OS	Tertile	III,IV	0.621	0.308	<.001	96	view →
KIRC	DFS	Tertile	All	0.448	0.685	<.001	86	view →
UCEC	OS	Tertile	All	0.971	0.899	.002	40	view →
THCA	OS	Tertile	II,III,IV	0.875	0.975	.003	36	view →
LIHC	OS	Tertile	All	0.170	0.569	<.001	33	view →
HNSC	DFS	Tertile	All	0.632	0.290	.019	30	view →
BRCA	OS	Tertile	All	0.978	0.940	.012	24	view →
LUAD	OS	Median	All	0.483	0.227	.003	24	view →
KICH	OS	Tertile	III,IV	0.178	0.847	<.001	18	view →
SCLC	DFS	Tertile	II,III,IV	0.274	0.792	.036	9	view →
PCPG	DFS	Tertile	All	0.161	0.819	.004	9	view →
SKCM	OS	Tertile	III,IV	0.925	0.793	.031	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 17 lineages.

WFDC6–BLCA (OS)

Open the BLCA breakdown →