WFDC6

Across TCGA cell cohorts, WFDC6 RNA expression is significantly associated with the mutation status of many other genes, with 158 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible WFDC6-associated genes across cancer lineages are PKHD1L1, XRN2, and MYBBP1A. Each is linked with WFDC6 in more than 1 cancer types. Because this analysis shows association rather than direction, both WFDC6-to-partner and partner-to-WFDC6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PKHD1L1 grouped by WFDC6-low versus WFDC6-high in URINARY_TRACT.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WFDC6→partner) and Y-score (partner→WFDC6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	PKHD1L1 →	+2.678	+0.081	.002	<.001	3	2
LUNG_NSCLC_LUSC	XRN2 →	+4.643	+0.060	.008	<.001	3	2
LUNG_NSCLC_LUAD	MYBBP1A →	+4.887	+0.057	.009	<.001	3	2
LUNG_NSCLC_LUAD	SHROOM2 →	+4.887	+0.050	.009	<.001	3	2
LUNG_NSCLC_LUAD	SPAG17 →	+3.472	+0.041	.004	<.001	3	2
LUNG_NSCLC_LUAD	RYR1 →	+1.887	+0.016	.002	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 158 associations by consensus.

PKHD1L1 by WFDC6 expression — URINARY_TRACT

Explore this box plot interactively →