WFDC21P

Across TCGA pan-cancer cohorts, WFDC21P RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated WFDC21P data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher WFDC21P RNA is associated with better overall survival. In most high-consensus cancer types, elevated WFDC21P expression acts as an unfavorable survival marker, although some lineages such as HNSC and CESC show a favorable association.

HNSC, BRCA, and CESC are the cancer types where WFDC21P RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	III,IV	0.444	0.213	<.001	121	view →
BRCA	DFS	Median	III,IV	0.705	0.878	<.001	43	view →
CESC	DFS	Tertile	All	0.903	0.764	.002	40	view →
UCS	DFS	Tertile	IV	0.275	0.861	.024	30	view →
KIRP	OS	Median	All	0.986	0.903	.004	28	view →
UVM	DFS	Tertile	III,IV	0.205	0.634	.013	24	view →
LIHC	OS	Median	III,IV	0.405	0.770	<.001	24	view →
BLCA	OS	Quartile	III,IV	0.779	0.547	.002	22	view →
KIRC	DFS	Median	All	0.768	0.837	.012	20	view →
LGG	OS	Quartile	All	0.320	0.769	<.001	17	view →
LUSC	DFS	Quartile	III,IV	0.603	0.196	.003	16	view →
CHOL	DFS	Quartile	II,III,IV	0.813	0.173	.004	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

WFDC21P–HNSC (OS)

Open the HNSC breakdown →