WFDC21P

Across TCGA pan-cancer cohorts, WFDC21P RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of WFDC21P’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where WFDC21P RNA is repressed in tumor relative to normal tissue. In most cancer types WFDC21P is over-expressed in tumor, although a few such as HNSC and KICH show the opposite, repressed pattern.

HNSC, KIRP, and BRCA are the cancer types where WFDC21P tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in WFDC21P RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	IV	−2.541	<.001	12	view →
KIRP	All	III,IV	+3.080	<.001	11	view →
BRCA	Female	All	+1.168	<.001	6	view →
LIHC	Female	All	+0.978	<.001	4	view →
COAD	All	All	+0.646	.010	4	view →
KICH	Female	All	−1.773	<.001	3	view →
CHOL	All	All	+1.738	.001	3	view →
KIRC	Male	All	+0.571	.011	3	view →
LUSC	All	All	+0.913	.005	2	view →
PRAD	All	All	−0.333	.022	2	view →
STAD	Male	IV	−1.900	.034	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

WFDC21P–HNSC

Open the HNSC breakdown →