WFDC2

Across TCGA patient cohorts, WFDC2 mutation is significantly associated with the RNA expression of many other genes, with 243 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible WFDC2-associated genes across cancer lineages are MIR513A2, LINC00313, and PLA2G2E. Each is linked with WFDC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both WFDC2-to-partner and partner-to-WFDC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR513A2 grouped by WFDC2-low versus WFDC2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WFDC2→partner) and Y-score (partner→WFDC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	MIR513A2 →	+0.091	+4.049	<.001	.007	3	2
UCEC	LINC00313 →	+0.070	+3.640	<.001	.008	3	1
UCEC	PLA2G2E →	+0.398	+3.693	<.001	.007	3	1
UCEC	OR51A8P →	+0.108	+3.488	.002	.008	3	1
UCEC	MIR425 →	+0.574	+3.914	.003	.002	3	1
UCEC	RNU6-228P →	+0.569	+3.863	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 243 associations by consensus.

MIR513A2 by WFDC2 expression — SKCM

Explore this box plot interactively →