WFDC13

Across TCGA cell cohorts, WFDC13 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,015 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible WFDC13-associated GO terms across cancer lineages are Regulation of homotypic cell-cell adhesion, Positive regulation of intracellular transport, and Cytoplasmic pattern recognition receptor signaling pathway. Each is linked with WFDC13 in more than 5 cancer types. Because this analysis shows association rather than direction, both WFDC13-to-partner and partner-to-WFDC13 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of homotypic cell-cell adhesion grouped by WFDC13-low versus WFDC13-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (WFDC13→partner) and Y-score (partner→WFDC13) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Regulation of homotypic cell-cell adhesion →	+0.152	+0.029	<.001	.002	3	5
UPPER_AERODIGESTIVE_TRACT	Positive regulation of intracellular transport →	+0.058	+0.039	.002	.002	2	6
LUNG_NSCLC_LUAD	Cytoplasmic pattern recognition receptor signaling pathway →	+0.066	+0.173	<.001	.002	3	5
LUNG_NSCLC_LUAD	Negative regulation of response to biotic stimulus →	+0.069	+0.157	<.001	.004	3	5
LUNG_NSCLC_LUAD	Viral budding via host ESCRT complex →	+0.071	+0.119	<.001	.002	3	5
SOFT_TISSUE	Positive regulation of focal adhesion assembly →	+0.119	+0.027	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,015 associations by consensus.

Regulation of homotypic cell-cell adhesion by WFDC13 expression — SOFT_TISSUE

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