WFDC13

Across TCGA pan-cancer cohorts, WFDC13 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of WFDC13’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where WFDC13 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types WFDC13 is over-expressed in tumor, although a few such as LUSC and KICH show the opposite, repressed pattern.

KIRC, LUSC, and COAD are the cancer types where WFDC13 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in WFDC13 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	III,IV	+0.091	<.001	10	view →
LUSC	Female	All	−0.372	<.001	7	view →
COAD	All	II,III,IV	+0.145	.005	5	view →
BRCA	All	All	+0.195	<.001	4	view →
READ	All	III,IV	+0.279	.043	2	view →
STAD	All	IV	+0.106	.031	1	view →
KIRP	Female	All	+0.082	.041	1	view →
KICH	Female	All	−0.056	.047	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

WFDC13–KIRC

Open the KIRC breakdown →