WFDC12

Across TCGA cell cohorts, WFDC12 RNA expression is significantly associated with the go_rna of many other GO terms, with 499 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible WFDC12-associated GO terms across cancer lineages are Copulation, Positive regulation of nuclear-transcribed mRNA poly(A) tail shortening, and Negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction. Each is linked with WFDC12 in more than 4 cancer types. Because this analysis shows association rather than direction, both WFDC12-to-partner and partner-to-WFDC12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Copulation grouped by WFDC12-low versus WFDC12-high in CNS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (WFDC12→partner) and Y-score (partner→WFDC12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	Copulation →	+1.086	+0.027	<.001	.003	3	4
PANCREAS	Positive regulation of nuclear-transcribed mRNA poly(A) tail shortening →	+0.076	+0.175	.002	.008	2	5
UPPER_AERODIGESTIVE_TRACT	Negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction →	+0.081	+1.563	<.001	.003	3	3
UPPER_AERODIGESTIVE_TRACT	Mating behavior →	+0.220	+1.620	<.001	.003	3	3
UPPER_AERODIGESTIVE_TRACT	Hypoxia-inducible factor-1alpha signaling pathway →	-1.275	-1.040	<.001	.001	3	3
SOFT_TISSUE	Regulation of plasma cell differentiation →	+0.117	+0.018	.007	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 499 associations by consensus.

Copulation by WFDC12 expression — CNS

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