WFDC12

Across TCGA pan-cancer cohorts, WFDC12 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated WFDC12 data layer compared with 1 for mass-spec protein.

The strongest signal is observed in ovarian serous cystadenocarcinoma (OV), where higher WFDC12 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated WFDC12 expression acts as an unfavorable survival marker, although some lineages such as ESCA and KIRP show a favorable association.

OV, KIRC, and UCS are the cancer types where WFDC12 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
OV	OS	Median	IV	0.603	0.883	.004	100	view →
KIRC	DFS	Median	All	0.547	0.702	<.001	72	view →
UCS	DFS	Tertile	III,IV	0.243	0.535	.007	68	view →
SKCM	OS	Median	II,III,IV	0.656	0.775	.003	56	view →
UCEC	DFS	Median	All	0.796	0.880	.003	34	view →
KICH	OS	Tertile	All	0.601	0.955	.014	30	view →
ESCA	OS	Median	III,IV	0.783	0.385	<.001	30	view →
KIRP	OS	Median	All	0.965	0.897	.007	27	view →
CESC	DFS	Median	III,IV	0.769	0.397	.001	24	view →
BLCA	OS	Quartile	IV	0.253	0.641	.004	22	view →
HNSC	OS	Quartile	All	0.562	0.221	.002	21	view →
TGCT	DFS	Tertile	II,III,IV	0.621	0.949	.034	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

WFDC12–OV (OS)

Open the OV breakdown →