Across TCGA pan-cancer cohorts, WFDC10B RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated WFDC10B data layer compared with 3 for mutation status.
The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher WFDC10B RNA is associated with worse overall survival. In most high-consensus cancer types, elevated WFDC10B expression acts as an unfavorable survival marker, although some lineages such as LUAD and ACC show a favorable association.
KIRC, KIRP, and COAD are the cancer types where WFDC10B RNA most reproducibly stratifies survival.
RNA survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.