Across TCGA pan-cancer cohorts, WFDC10B RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of WFDC10B’s most consistent transcriptional readouts.
The strongest signal is observed in colon adenocarcinoma (COAD), where WFDC10B RNA is more highly expressed in tumor relative to normal tissue. In most cancer types WFDC10B is over-expressed in tumor, although a few such as LUSC and PRAD show the opposite, repressed pattern.
COAD, KIRC, and PAAD are the cancer types where WFDC10B tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in WFDC10B RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.