Across TCGA pan-cancer cohorts, WFDC10B Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated WFDC10B data layer compared with 22 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher WFDC10B Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated WFDC10B expression acts as an unfavorable survival marker.

HNSC, ACC, and LIHC are the cancer types where WFDC10B Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.057	0.768	<.001	45	view →
ACC	DFS	Median	All	0.010	0.667	<.001	45	view →
LIHC	DFS	Median	All	0.044	0.553	<.001	12	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: WFDC10B tumor-vs-normal RNA expression · all WFDC10B data types