WFDC10A

Across TCGA patient cohorts, WFDC10A mutation is significantly associated with the RNA expression of many other genes, with 48 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WFDC10A-associated genes across cancer lineages are MIR1278, RN7SL83P, and RNU6-247P. Each is linked with WFDC10A in more than 1 cancer types. Because this analysis shows association rather than direction, both WFDC10A-to-partner and partner-to-WFDC10A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR1278 grouped by WFDC10A-low versus WFDC10A-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WFDC10A→partner) and Y-score (partner→WFDC10A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	MIR1278 →	+0.462	+5.970	<.001	.002	3	2
UCEC	RN7SL83P →	+0.273	+3.398	<.001	.001	3	2
SKCM	RNU6-247P →	+0.554	+4.979	<.001	.009	3	2
UCEC	SNX3P1Y →	+0.179	+5.478	<.001	<.001	3	1
UCEC	MIR378E →	+0.463	+4.231	<.001	<.001	3	1
UCEC	MAPKBP1 →	+0.565	+3.210	.002	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 48 associations by consensus.

MIR1278 by WFDC10A expression — SKCM

Explore this box plot interactively →