WFDC10A

Across TCGA pan-cancer cohorts, WFDC10A RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated WFDC10A data layer compared with 1 for mutation status.

The strongest signal is observed in cholangiocarcinoma (CHOL), where higher WFDC10A RNA is associated with worse overall survival. In most high-consensus cancer types, elevated WFDC10A expression acts as an unfavorable survival marker, although some lineages such as OV and PAAD show a favorable association.

CHOL, HNSC, and OV are the cancer types where WFDC10A RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CHOL	OS	Tertile	All	0.253	0.817	<.001	108	view →
HNSC	OS	Tertile	All	0.328	0.632	<.001	78	view →
OV	OS	Median	All	0.384	0.279	.001	76	view →
DLBC	DFS	Tertile	II,III,IV	0.065	0.829	<.001	63	view →
THYM	OS	Tertile	All	0.746	0.980	<.001	51	view →
PAAD	DFS	Median	All	0.600	0.334	<.001	45	view →
KIRP	OS	Tertile	All	0.636	0.919	.001	42	view →
LUSC	OS	Tertile	II,III,IV	0.193	0.434	.007	39	view →
LIHC	DFS	Quartile	II,III,IV	0.226	0.526	.001	27	view →
KIRC	OS	Tertile	All	0.477	0.657	.005	24	view →
UVM	OS	Quartile	All	0.929	0.514	.009	23	view →
GBM	DFS	Tertile	All	0.109	0.311	.002	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

WFDC10A–CHOL (OS)

Open the CHOL breakdown →