WFDC10A

Across TCGA patient cohorts, WFDC10A mutation is significantly associated with the total protein of many other genes, with 2 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WFDC10A-associated genes across cancer lineages are 4E-BP1 and BRD4. Each is linked with WFDC10A in more than 1 cancer types. Because this analysis shows association rather than direction, both WFDC10A-to-partner and partner-to-WFDC10A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by WFDC10A-low versus WFDC10A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WFDC10A→partner) and Y-score (partner→WFDC10A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.538	+2.837	.001	.035	3	1
UCEC	BRD4 →	+0.386	+2.814	.018	.036	1	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

4E-BP1 by WFDC10A expression — UCEC

Explore this box plot interactively →