WFDC10A

Across TCGA cell cohorts, WFDC10A RNA expression is significantly associated with the go_rna of many other GO terms, with 294 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible WFDC10A-associated GO terms across cancer lineages are piRNA-mediated gene silencing by mRNA destabilization, Serotonin metabolic process, and Lymphocyte migration. Each is linked with WFDC10A in more than 2 cancer types. Because this analysis shows association rather than direction, both WFDC10A-to-partner and partner-to-WFDC10A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, piRNA-mediated gene silencing by mRNA destabilization grouped by WFDC10A-low versus WFDC10A-high in LARGE_INTESTINE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (WFDC10A→partner) and Y-score (partner→WFDC10A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	piRNA-mediated gene silencing by mRNA destabilization →	-0.260	-0.341	<.001	.003	3	3
LARGE_INTESTINE	Serotonin metabolic process →	+0.150	+0.270	<.001	.001	3	3
OVARY	Lymphocyte migration →	+0.148	+0.020	.001	.004	3	2
OVARY	Negative regulation of protein deubiquitination →	+0.124	+0.034	<.001	.005	3	2
OVARY	Pyrimidine ribonucleotide metabolic process →	-0.065	-0.020	.002	.005	3	2
SKIN	Protein localization to cell leading edge →	+0.091	+0.044	.009	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 294 associations by consensus.

piRNA-mediated gene silencing by mRNA destabilization by WFDC10A expression — LARGE_INTESTINE

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