WFDC1

Across TCGA patient cohorts, WFDC1 mutation is significantly associated with the RNA expression of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WFDC1-associated genes across cancer lineages are RNU4-65P, TSPY7P, and NUTF2P8. Each is linked with WFDC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both WFDC1-to-partner and partner-to-WFDC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU4-65P grouped by WFDC1-low versus WFDC1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WFDC1→partner) and Y-score (partner→WFDC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU4-65P →	+0.429	+4.453	<.001	.006	3	2
HNSC	TSPY7P →	+0.039	+7.954	<.001	.008	3	1
UCEC	NUTF2P8 →	+0.156	+3.982	.001	.003	3	1
UCEC	RN7SL750P →	+0.452	+4.435	<.001	.001	3	1
UCEC	MIR4511 →	+0.646	+4.242	<.001	.002	3	1
UCEC	RN7SL376P →	+0.312	+4.400	.002	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

RNU4-65P by WFDC1 expression — UCEC

Explore this box plot interactively →