Across TCGA patient cohorts, WEE2 mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WEE2-associated genes across cancer lineages are ATM, EGFR_pY1068, and eIF4E. Each is linked with WEE2 in more than 2 cancer types. Because this analysis shows association rather than direction, both WEE2-to-partner and partner-to-WEE2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WEE2→partner) and Y-score (partner→WEE2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.480	-2.401	<.001	.002	3	3
UCEC	EGFR_pY1068 →	-0.196	-1.289	.014	.023	3	2
UCEC	eIF4E →	+0.180	+3.713	.007	<.001	3	2
UCEC	FOXO3a_pS318_S321 →	-0.095	-1.838	.016	.007	3	2
UCEC	NF-kB-p65_pS536 →	-0.288	-2.584	.047	.010	3	2
UCEC	PCNA →	+0.239	+2.378	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

Exploration

WEE2 survival (RNA) · tumor vs normal (RNA) · all WEE2 data types