Across TCGA cell cohorts, WEE2 mutation is significantly associated with the RNA expression of many other genes, with 54 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible WEE2-associated genes across cancer lineages are TSHZ3, SLC28A2, and KCNH1. Each is linked with WEE2 in more than 1 cancer types. Because this analysis shows association rather than direction, both WEE2-to-partner and partner-to-WEE2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WEE2→partner) and Y-score (partner→WEE2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	TSHZ3 →	+1.060	+3.212	.001	.006	3	1
SKIN	SLC28A2 →	+0.046	+3.067	<.001	.009	3	1
SKIN	KCNH1 →	+0.911	+3.064	.006	.009	3	1
SKIN	BDP1 →	+0.429	+3.212	.007	.006	3	1
SKIN	DKK2 →	+0.545	+3.385	.003	.004	3	1
SKIN	SLC2A6 →	+1.171	+3.212	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 54 associations by consensus.

Exploration

WEE2 survival (RNA) · tumor vs normal (RNA) · all WEE2 data types