Across TCGA cell cohorts, WEE2 mutation is significantly associated with the mutation status of many other genes, with 4,600 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible WEE2-associated genes across cancer lineages are SCN4A, DNAH2, and ZNF560. Each is linked with WEE2 in more than 4 cancer types. Because this analysis shows association rather than direction, both WEE2-to-partner and partner-to-WEE2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WEE2→partner) and Y-score (partner→WEE2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	SCN4A →	+4.562	+5.217	<.001	<.001	1	5
CNS	DNAH2 →	+3.029	+4.491	.004	.004	1	4
CNS	ZNF560 →	+4.614	+4.614	.006	.006	1	4
OVARY	PLXNA4 →	+2.977	+4.273	.006	.006	1	4
CNS	COBL →	+4.614	+4.614	.006	.006	1	4
OVARY	DPP6 →	+3.240	+4.467	.004	.004	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,600 associations by consensus.

Exploration

WEE2 survival (RNA) · tumor vs normal (RNA) · all WEE2 data types