WDR90

Across TCGA patient cohorts, WDR90 mutation is significantly associated with the total protein of many other genes, with 54 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WDR90-associated genes across cancer lineages are Caspase-7-cleavedD198, Cyclin-E2, and HER2_pY1248. Each is linked with WDR90 in more than 2 cancer types. Because this analysis shows association rather than direction, both WDR90-to-partner and partner-to-WDR90 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by WDR90-low versus WDR90-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WDR90→partner) and Y-score (partner→WDR90) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+1.160	+3.338	<.001	.004	3	3
COAD	Cyclin-E2 →	+0.180	+3.347	.048	.004	3	3
SKCM	HER2_pY1248 →	-0.155	-2.584	.014	.009	3	3
BLCA	Chk1 →	+0.321	+2.824	.027	.036	3	2
UCEC	EGFR_pY1068 →	-0.227	-1.473	.003	.006	3	2
UCEC	A-Raf_pS299 →	-0.112	-2.584	.002	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 54 associations by consensus.

Caspase-7-cleavedD198 by WDR90 expression — COAD

Explore this box plot interactively →