WDR90

Across TCGA cell cohorts, WDR90 mutation is significantly associated with the mutation status of many other genes, with 5,682 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible WDR90-associated genes across cancer lineages are SHANK1, BICRA, and COL6A6. Each is linked with WDR90 in more than 5 cancer types. Because this analysis shows association rather than direction, both WDR90-to-partner and partner-to-WDR90 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SHANK1 grouped by WDR90-low versus WDR90-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WDR90→partner) and Y-score (partner→WDR90) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SHANK1 →	+2.640	+2.235	.004	.004	1	6
BLOOD_Leukemia	BICRA →	+2.792	+2.967	<.001	<.001	1	6
LARGE_INTESTINE	COL6A6 →	+2.362	+2.479	<.001	<.001	1	6
CNS	FRAS1 →	+2.521	+2.974	.002	.002	1	6
OESOPHAGUS	PHLPP1 →	+4.672	+4.672	.001	.001	1	5
SKIN	MGA →	+3.455	+3.455	<.001	<.001	1	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,682 associations by consensus.

SHANK1 by WDR90 expression — BLOOD_Leukemia

Explore this box plot interactively →