WDR81

Across TCGA patient cohorts, WDR81 mutation is significantly associated with the total protein of many other genes, with 51 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WDR81-associated genes across cancer lineages are PDCD4, ATM, and Caspase-7-cleavedD198. Each is linked with WDR81 in more than 2 cancer types. Because this analysis shows association rather than direction, both WDR81-to-partner and partner-to-WDR81 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDCD4 grouped by WDR81-low versus WDR81-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WDR81→partner) and Y-score (partner→WDR81) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PDCD4 →	-0.350	-1.584	.008	.032	3	3
UCEC	ATM →	-0.448	-2.044	<.001	<.001	3	3
COAD	Caspase-7-cleavedD198 →	+1.017	+2.123	.001	.010	3	3
COAD	TFRC →	+0.521	+1.610	.012	.042	3	3
COAD	E-Cadherin →	-0.554	-3.000	.026	.034	3	3
UCEC	14-3-3_beta →	-0.081	-2.388	.004	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 51 associations by consensus.

PDCD4 by WDR81 expression — UCEC

Explore this box plot interactively →