WDR81

Across TCGA pan-cancer cohorts, WDR81 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated WDR81 data layer compared with 10 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher WDR81 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated WDR81 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SCLC show a favorable association.

HNSC, SCLC, and KIRC are the cancer types where WDR81 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	III,IV	0.446	0.158	<.001	88	view →
SCLC	OS	Median	All	0.713	0.416	<.001	85	view →
KIRC	DFS	Median	III,IV	0.791	0.476	<.001	70	view →
ESCA	OS	Quartile	II,III,IV	0.731	0.373	.002	51	view →
UCEC	DFS	Median	III,IV	0.719	0.435	.002	50	view →
LUSC	DFS	Tertile	III,IV	0.398	0.951	.006	25	view →
CESC	OS	Median	IV	0.828	0.333	.004	24	view →
PAAD	OS	Median	II,III,IV	0.676	0.446	.002	21	view →
OV	OS	Tertile	III,IV	0.337	0.439	.015	20	view →
BLCA	DFS	Median	All	0.268	0.400	.005	20	view →
BRCA	DFS	Tertile	III,IV	0.637	0.431	<.001	17	view →
SKCM	OS	Tertile	II,III,IV	0.645	0.796	.021	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

WDR81–HNSC (DFS)

Open the HNSC breakdown →