WDR76

Across TCGA pan-cancer cohorts, WDR76 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated WDR76 data layer compared with 28 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher WDR76 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated WDR76 expression acts as an unfavorable survival marker, although some lineages such as LSCC show a favorable association.

PDAC, HNSC, and LSCC are the cancer types where WDR76 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Tertile	II,III,IV	0.530	0.976	.005	33	view →
HNSC	OS	Median	III,IV	0.296	1.000	.005	24	view →
LSCC	DFS	Quartile	All	0.911	0.641	.015	7	view →
CCRCC	DFS	Median	II,III,IV	0.284	1.000	.013	6	view →
LUAD	DFS	Median	II,III,IV	0.197	0.864	.012	5	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

WDR76–PDAC (OS)

Open the PDAC breakdown →