WDR75

Across TCGA pan-cancer cohorts, WDR75 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated WDR75 data layer compared with 20 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher WDR75 Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated WDR75 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

UCEC, OV, and LUSC are the cancer types where WDR75 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	1.000	0.827	.007	32	view →
OV	OS	Median	All	0.362	0.842	.005	18	view →
LUSC	OS	Median	II,III,IV	0.216	0.745	<.001	12	view →
SKCM	DFS	Median	III,IV	0.015	0.648	<.001	3	view →
COAD	OS	Median	II,III,IV	0.269	0.606	.027	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

WDR75–UCEC (DFS)

Open the UCEC breakdown →