WDR75

Across TCGA pan-cancer cohorts, WDR75 RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of WDR75’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where WDR75 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types WDR75 is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

HNSC, LUAD, and KIRC are the cancer types where WDR75 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in WDR75 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	IV	+1.250	<.001	12	view →
LUAD	Male	II,III,IV	+1.004	<.001	11	view →
KIRC	Female	All	+0.564	<.001	11	view →
COAD	Male	IV	+1.279	<.001	10	view →
STAD	Male	II,III,IV	+1.185	<.001	9	view →
LIHC	Male	II,III,IV	+1.081	<.001	9	view →
BLCA	All	All	+0.611	<.001	9	view →
KICH	Female	All	−1.420	<.001	8	view →
LUSC	Male	All	+1.223	<.001	8	view →
KIRP	All	II,III,IV	+0.628	.003	8	view →
READ	All	All	+1.313	<.001	7	view →
BRCA	All	II,III,IV	+0.404	<.001	6	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

WDR75–HNSC

Open the HNSC breakdown →