WDR75

Across TCGA pan-cancer cohorts, WDR75 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated WDR75 data layer compared with 20 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher WDR75 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated WDR75 expression acts as an unfavorable survival marker, although some lineages such as LUAD and LSCC show a favorable association.

CCRCC, LUAD, and LSCC are the cancer types where WDR75 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Median	All	0.740	0.928	<.001	92	view →
LUAD	DFS	Median	III,IV	0.716	0.253	.006	12	view →
LSCC	DFS	Tertile	II,III,IV	0.903	0.521	.007	12	view →
PDAC	DFS	Quartile	All	0.285	0.542	.022	9	view →
HNSC	DFS	Median	III,IV	0.697	0.872	.024	3	view →
GBM	DFS	Quartile	All	0.761	0.874	.025	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

WDR75–CCRCC (OS)

Open the CCRCC breakdown →