WDR75

Across TCGA patient cohorts, WDR75 mutation is significantly associated with the RNA expression of many other genes, with 1,385 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WDR75-associated genes across cancer lineages are RN7SKP181, JAKMIP1, and CD96. Each is linked with WDR75 in more than 1 cancer types. Because this analysis shows association rather than direction, both WDR75-to-partner and partner-to-WDR75 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SKP181 grouped by WDR75-low versus WDR75-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WDR75→partner) and Y-score (partner→WDR75) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RN7SKP181 →	+0.183	+6.878	<.001	<.001	3	2
UCEC	JAKMIP1 →	+0.487	+2.502	.001	.001	3	2
UCEC	CD96 →	+0.613	+2.178	<.001	.001	3	2
UCEC	CD8A →	+1.034	+1.960	<.001	<.001	3	2
UCEC	GBP5 →	+1.241	+2.273	<.001	<.001	3	2
UCEC	FLCN →	+0.417	+3.711	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,385 associations by consensus.

RN7SKP181 by WDR75 expression — BRCA

Explore this box plot interactively →