WDR75

Across TCGA patient cohorts, WDR75 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WDR75-associated genes across cancer lineages are ATM, Caspase-7-cleavedD198, and 14-3-3_beta. Each is linked with WDR75 in more than 1 cancer types. Because this analysis shows association rather than direction, both WDR75-to-partner and partner-to-WDR75 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by WDR75-low versus WDR75-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WDR75→partner) and Y-score (partner→WDR75) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.403	-2.571	.011	.010	3	2
UCEC	Caspase-7-cleavedD198 →	+0.923	+3.807	<.001	<.001	3	2
UCEC	14-3-3_beta →	-0.097	-1.780	.006	.024	3	1
UCEC	A-Raf_pS299 →	-0.140	-2.222	<.001	.010	3	1
UCEC	ERK2 →	+0.175	+1.662	.010	.011	3	1
UCEC	FOXO3a →	-0.072	-3.308	.044	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

ATM by WDR75 expression — UCEC

Explore this box plot interactively →