WDR75

Across TCGA cell cohorts, WDR75 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,205 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible WDR75-associated GO terms across cancer lineages are Transcription initiation at RNA polymerase I promoter, Maturation of SSU-rRNA, and IMP biosynthetic process. Each is linked with WDR75 in more than 17 cancer types. Because this analysis shows association rather than direction, both WDR75-to-partner and partner-to-WDR75 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Transcription initiation at RNA polymerase I promoter grouped by WDR75-low versus WDR75-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (WDR75→partner) and Y-score (partner→WDR75) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Transcription initiation at RNA polymerase I promoter →	+0.142	+1.396	<.001	<.001	3	18
BLOOD_Lymphoma	Maturation of SSU-rRNA →	+0.117	+1.050	<.001	<.001	3	17
URINARY_TRACT	IMP biosynthetic process →	+0.197	+1.048	.002	<.001	3	17
BONE	Metaphase/anaphase transition of cell cycle →	+0.172	+0.993	.003	.002	3	17
BONE	Metaphase/anaphase transition of mitotic cell cycle →	+0.172	+0.993	.003	.002	3	17
BONE	Ribosomal small subunit biogenesis →	+0.105	+1.084	.002	.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,205 associations by consensus.

Transcription initiation at RNA polymerase I promoter by WDR75 expression — BONE

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